This study was conducted to aim predict depression based on mindwandering (deliberate-spontaneous) and mindfulness variable in students with the correlation method.380 students of Allame Tabatabai University were selected using voluntary method and complete Beck Depression Inventory, Deliberate and Spontaneous Mind Wandering and Five Facets of Mindfulness (FFMQ). Data were analyzed using Pearson correlation- coefficient method and multiple regression. Results showed that deliberate mind wandering and spontaneous mind wandering have positive and direct relationship with depression and between the components of mindfulness, the components of description، action with awareness, disrespect to inner experience and lack of reaction to inner experience have a negative relationship with depression. Also, the results from concurrent regression analyis showed that from mind wandering components, only spontaneous mind wandeing variable and from mindfulness components, only observation, act with awarness, non-judgmental orientation to one’s present experience and nonreact orientation to one’s present experience,respectively, can predict depression.Based on these findings, we can conclude that striving for excellence; spontaneous mind wandeing and observation, act with awarness, non-judgmental orientation to one’s present experience and nonreact orientation to one’s present experience, were the main determinants of depression in students.